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Marc C. Peden, MD

Education:

  1. University of Florida College of Medicine Department of Ophthalmology:
    Vitreoretinal Surgery and Disease Fellowship
    Gainesville, Florida
    7/1/2007 to 6/30/2009
  2. University of Florida College of Medicine Department of Ophthalmology: Residency
    Gainesville, Florida
    7/1/2004 to 6/30/2007
  3. University of Florida College of Medicine Department of Internal Medicine: Internship
    Gainesville, Florida
    7/1/2003-6/30/2004
  4. University of Florida College of Medicine
    Gainesville, Florida
    M.D., Awarded May 24, 2003 with Academic Honors
  5. University of Florida
    Gainesville, Florida
    B.S. in Zoology with High Honors, minor in Business Administration, 1997

Academic Appointments:

  1. University of Florida Department of Ophthalmology
    Adjunct Assistant Professor 12/16/2011-current
    Gainesville, Florida
  2. University of Florida Department of Ophthalmology
    Assistant Professor 7/6/2009-12/16/2011
    Director of Vitreo-retinal Disease and Surgery Service 11/2010-12/16/2011
    Gainesville, Florida

Hospital Appointments:

  1. Memorial Hospital of Tampa
    Tampa, Florida
    12/13/2011-current
  2. Tampa General Hospital
    Tampa, FL
    1/1/2013- current     
  3. Shands Hospital at the University of Florida
    Gainesville, Florida
    7/2003-12/2011

Licensure/Certification:

  1. American Board of Ophthalmology:
    Written Qualifying Exam, passed 3/2008
    Oral Qualifying Exam, passed 10/2008
  2. Florida Medical Board: issued 6/21/06, expires 1/31/20 License # ME96228

Professional Memberships:

  1. American Academy of Ophthalmology 2004-current
  2. American Society of Retina Specialists 2009-current
  3. Association for Research in Vision and Ophthalmology 2005-current
  4. Florida Society of Ophthalmology 2007-current
  5. American Medical Association 1999-2007
  6. Florida Medical Association 1999-current
  7. Tampa Bay Ophthalmologic Society 2012-current

Research Experience:

  1. University of Florida Center for Vision Research: 2009-current
    1. Co-Principle Investigators:Dr. Marc Peden MD,  and Dr. Mark Sherwood MD
      Project- AAV mediated gene delivery to the subretinal and suprachoroidal space via ab-externo approach using a 250 micron microcatheter,
    2. Co-Principal Investigators: Dr Marc Peden MD, and Dr. Tim Garrett PhD
      Project-Analysis of macular drusen in rhesus monkeys; an animal model of macular drusen
      Funding: Florida Lions Club
    3. Collaborator: NIH, R01 Grant, (1R01LM010813-01) (PI, 2nd PI: Cendan, Co-Is: Lind, Johnsen, Cuty-Ruiz) 2009-2011.   Project- Neurological Exams Teaching & Evaluation Using Virtual Patient.
  2. University of Florida Department of Ophthalmology, 2005-2006
    Faculty Advisor- Dr. Ramakrishna Ratnakaram MD, OD
    Project- The effect of intravitreal silicone oil on intraocular pressure following pars plana vitrectomy.
  3. University of Florida Center for Vision Research, March-June 2003
    Principle Investigator- Dr. Shalesh Kaushal, MD,PhD.
    Mentor- Dr. Adrian Timmers PhD
    Project- Rescue of retinal function and rhodopsin folding in a P23H rat model of retinitis pigmentosa using injected isomers of retinaldehyde as chaperones.
  4. University of Florida Center for Vision Research, 1996-1997
    Principle Investigator-  Dr. Paul A. Hargrave PhD.
    Mentors- Dr. Clay Smith PhD.,&  Dr. Mick Popp PhD.
    Project- Molecular aspects of arrestin- determining surface regions of arrestin that interact with photo-excited rhodopsin.
    Senior Thesis- “Neutralization of lysine 201 in bovine arrestin via oligonucleotide-directed mutagenesis, and its effects on binding specificity.”-Received High Honors

Conference Presentations

  1. Therapeutic Approaches to the Posterior Eye- A Clinical Perspective, Marc Peden, Center for Vision Research meeting -“Development and Delivery of Therapeutic Agents for the Eye.”  March 8-9, 2010, Gainesville, FL.
  2. Long-term Visual Outcomes in Patients Receiving Continuous, Fixed-Interval Dosing of Anti-VEGF Agents for Wet Age-Related Macular Degeneration. 17th Annual Club Vit Meeting, 6/28-7/2/2014, Beaver Creek, CO.
  3. Long-term Visual Outcomes in Patients Receiving Continuous, Fixed-Interval Dosing of Anti-VEGF Agents for Wet Age-Related Macular Degeneration. ASRS Annual Meeting Scientific Program, August 9, 2014, San Diego, CA.
  4. FIDO Follow-up: 8 year outcomes in patients receiving FIDO protocol for wet AMD and comparison to other long-term studies. Florida Society of Ophthalmology Meeting, June 27, 2015, Palm Beach, FL.
  5. Revolutionary: A Novel Treatment Strategy for Branch Retinal Vein Occlusion Associated with Peripheral Retinal Nonperfusion. 18th Annual Club Vit Meeting, August 8-12, 2015, Southampton, Bermuda.
  6. Dilute povidone-iodine prophylaxis maintains safety while improving patient comfort after intravitreal injections. 20th Annual Club Vit Meeting, Jub 28- Jul 1, 2017, Mykonos, Greece.

Posters

  1. Dilute povidone-iodine prophylaxis maintains safety while improving patient comfort after intravitreal injections., Marc C. Peden MD, Mark E. Hammer MD, Ivan J Suñer MD, ASRS Annual Meeting, August 12-15, 2017, Boston, MA.
  2. Visual Acuity Impairment Under Low Luminance Conditions at Baseline Is a Powerful Predictor of Visual Acuity Response to Ranibizumab Therapy in Patients With Neovascular Age-related Macular Degeneration, Marc C. Peden, MD; Ronald E. Frenkel, MD; Howard Shapiro, PhD; Ivaylo Stoilov, MD, ARVO Annual Meeting, May 3-7, 2015, Denver, CO.
  3. REVOLUTIONARY: A Pilot Trial of Combination Peripheral Scatter Laser and Ranibizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion, Ivan J. Suner, Marc C. Peden, Mark E. Hammer, ASRS Annual Meeting Aug 9-13, 2014, San Diego, CA.
  4. Long-term stability of vision in patients receiving consistent, fixed interval dosing of anti-VEGF therapy for wet AMD over 5+ years, Marc C Peden, Ivan J Suner, Mark E Hammer, W. Sanderson Grizzard, ASRS Annual Meeting, Aug 24-29, 2013, Toronto, Canada.
  5. Successful Genetic Transfer of GFP to Outer Retina via Suprachoroidal Delivery Method with AAV2 Triple Mutant, AAV2, and AAV5 vectors, M. C. Peden MD,  G. Martorana,  M. Levine,   S Boye,   C. Meyers,  S. Boye PhD,  J. Min,  Z. Lukowski MD, M. Sherwood MD, ASRS Annual Meeting, Aug 25-29, 2012, Las Vegas, NV.
  6. Pan-retinal Photocoagulation In High-risk Non-proliferative Diabetic Retinopathy, Cristos Ifantides, Barrett Eubanks, Daniel Taylor, Marc Peden, ARVO Annual Meeting May 6, 2012, Fort Lauderdale, FL.
  7. Comparison of Suprachoroidal delivery via an Ab-Externo approach with the iTrack Microcatheter versus Vitrectomy and subretinal delivery for 3 different AAV Serotypes for Gene Transfer to the Retina, Gina Martorana, Monica Levine, Marc Peden, Shannon Boye,  Zachary Lukowski, Jeffrey Min, Craig Meyers, Sanford Boye, Mark Sherwood, ARVO Annual Meeting, May 7, 2012, Fort Lauderdale, FL.
  8. Safety Study of Ab-Externo AAV Gene Transfer Delivery to the Subretinal and Suprachoroidal Space Using a 250 Micron Flexible Microcatheter, M. C. Peden, C. Meyers, Q. Li, R. Yamamoto, C. Roberts, J. Minn1, M. Levine, V. Chiodo, A. Lewin, W. Hauswirth, R. Ratnakaram, M. Sherwood, ARVO Annual Meeting May 3-May 7 2009, Fort Lauderdale, FL.
  9. Reduction of Macular Edema at One Hour Following Intravitreal Bevacizumab as Demonstrated by Serial OCTs, D.E. Welch, S. Adams, M. Peden, R. Ratnakaram, S. Kaushal, ARVO Annual Meeting April 27-May 1 2008, Fort Lauderdale, FL.
  10. An Alternative Technique for Implantation of Scleral-Fixated Intraocular Lens, M.C. Peden, S.G. Adams, Jr., B. Huffman, H. Adams, S. Kaushal, ARVO Annual Meeting April 27-May 1 2008, Fort Lauderdale, FL.
  11. Disciform Scarring in Macular Degeneration Correlates With Loss of Retinal Nerve Fiber Layer Thickness on Optical Coherence Tomography (OCT), M.H. Oltmanns, M. Peden, S. Adams, R. Ratnakaram, S. Kaushal,  ARVO Annual Meeting April 27-May 1 2008, Fort Lauderdale, FL.
  12. Wound Closure in Sutureless 23 Gauge Pars Plana Vitrectomy: Ubm, Slit Lamp Photography, and Iop Results, S.G. Adams, Jr., M. Peden, R. Ratnakaram, S. Kaushal, ARVO Annual Meeting April 27-May 1 2008, Fort Lauderdale, FL.
  13. Intravitreal Avastin vs Pegaptanib in treatment of choroidal neovascular membranes, Ratnakaram, M. Peden, S. Adams, ARVO Annual Meeting May 6-10, 2007, Fort Lauderdale, FL.
  14. Combination PDT and VEGF inhibitor therapy for exudative ARMD, S.G. Adams, M. Peden, R. Ratnakaram, ARVO Annual Meeting May 6-10, 2007, Fort Lauderdale, FL.
  15. Effect of silicone oil on intraocular pressure following pars plana vitrectomy, M.C. Peden, C.W. Sheets, S. Adams, H.D. Vaishnav, R. Ratnakaram, ARVO Annual Meeting, May 6-10, 2007, Fort Lauderdale, FL.

Publications

  1. Peden MC, Hammer ME, Suñer IJ. Dilute povidone-iodine prophylaxis maintains safety while improving patient comfort after intravitreal injections. Retina. 2018 Aug 23. [Epub ahead of print]
  2. Jampol LM, Glassman AR, Liu D, Aiello LP, Bressler NM, Duh EJ, Quaggin S, Wells JA, Wykoff CC; Diabetic Retinopathy Clinical Research Network. Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema. Ophthalmology 2018 Jul;125(7):1054-1063.
  3. Charng J, Cideciyan AV, Jacobson SG, Sumaroka A, Schwartz SB, Swider M, Roman AJ, Sheplock R, Anand M, Peden MC, Khanna H, Heon E, Wright AF, Swaroop A, Variegated yet non-random rod and cone photoreceptor disease patterns in RPGR-ORF15-associated retinal degeneration. Hum Mol Genet. 2016 Dec 15(24): 5444-5459.
  4. Wells JA, Glassman AR, Jampol LM, Aiello LP, Antoszyk AN, Baker CW, Bressler NM, Browning DJ, Connor CG, Elman MJ, Ferris FL, Friedman SM, Melia M, Pieramici DJ, Sun JK, Beck RW; Diabetic Retinopathy Clinical Research Network. Association of Baseline Visual Acuity and Retinal Thickness With 1-Year Efficacy of Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema.JAMA Ophthalmol. 2016 Feb;134(2):127-34.
  5. Diabetic Retinopathy Clinical Research Network., Wells JA, Glassman AR, Ayala AR, Jampol LM, Aiello LP, Antoszyk AN, Arnold-Bush B, Baker CW, Bressler NM, Browning DJ, Elman MJ, Ferris FL, Friedman SM, Melia M, Pieramici DJ, Sun JK, Beck RW. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015 Mar 26;372(13):1193-203.
  6. Friedman SM, Almukhtar TH, Baker CW, Glassman AR, Elman MJ, Bressler NM, Maker MP, Jampol LM, Melia M; Diabetic Retinopathy Clinical Research Network.. Topical nepafenec in eyes with noncentral diabetic macular edema. Retina. 2015 May;35(5):944-56.
  7. Peden MC, Suñer IJ, Hammer ME, Sanderson Grizzard W., Long-Term Outcomes in Eyes Receiving Fixed-Interval Dosing of Anti-Vascular Endothelial Growth Factor Agents for Wet Age-Related Macular Degeneration. Ophthalmology. 2015 Apr;122(4):803-8. doi: 10.1016/j.ophtha.2014.11.018. Epub 2015 Jan 14.
  8. Suñer IJ, Peden MC, Hammer ME, Grizzard WS, Traynom J, Cousins SW. RaScaL: A Pilot Study to Assess the Efficacy, Durability, and Safety of a Single Intervention with Ranibizumab plus Peripheral Laser for Diabetic Macular Edema Associated with Peripheral Nonperfusion on Ultrawide-Field Fluorescein Angiography. Ophthalmologica. 2014 Nov 26. [Epub ahead of print].
  9. M, Peden M, Kay C, Spectral Domain Optical Coherence Tomography Findings in CNGB3-Associated Achromatopsia, Adv Exp Med Biol. 2014;801:551-7. doi: 10.1007/978-1-4614-3209-8_70.
  10. Thomas J. Conlon, Wen-Tao Deng, Kirsten Erger, Travis Cossette, Ji-jing Pang, Renee Ryals, Nathalie Clement, Brian Cleaver, Issam McDoom,Shannon E. Boye, Marc C. Peden, Mark B. Sherwood, Corinne R. Abernathy, Fowzan S. Alkuraya, Sanford L. Boye, William W. Hauswirth. Preclinical Potency and Safety Studies of an AAV2-mediated Gene Therapy Vector for the Treatment of MERTK Associated Retinitis Pigmentosa. Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8.
  11. Hollsten JE, McClintock M, Samy H, Peden M, Kay CN. Fulminant chorioretinitis and papillitis secondary to coxsackievirus B virus presenting as acute posterior multifocal placoid pigment epitheliopathy with positive response to IVIG. Retina Cases and Brief Reports, 2013: Vol 7(3): 225-231.
  12. Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW, Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations: Safety and Efficacy in 15 Children and Adults Followed Up to 3 Years, Arch Ophthalmol. 2012 Jan;130(1):9-24.
  13. Peden M , Chuah J, Kotranza A, Johnsen K, Lok B, Cendan J, NERVE- A Three Dimensional Patient Simulation for Evaluating Cranial Nerve Function. MedEdPORTAL; 2011. Available from: http://services.aamc.org/30/mededportal/servlet/s/segment/mededportal/?subid=8255
  14. Peden M , Chuah J, Kotranza A, Johnsen K, Lok B, Cendan J, NERVE- 2: A Three Dimensional Patient Simulation of Oculomotor Nerve Palsy. MedEdPORTAL; 2010. Available from: http://services.aamc.org/30/mededportal/servlet/s/segment/mededportal/?subid=8383
  15. Knape RM, Zavaleta EM, Clark CL 3rd, Khuddus N, Peden MC. Intravitreal bevacizumab treatment of bilateral peripapillary choroidal neovascularization from optic nerve head drusen, J AAPOS. 2011 Feb;15(1):87-90.
  16. Bhardwaj N, Perez J, Peden M, Optic Neuropathy from Cobalt Toxicity in a Patient who Ingested Cattle Magnets, Neuro-Ophthalmology. Feb 2011;35(1): 24-26.
  17. M. C. Peden, J. Min,C. Meyers, Q. Li, R. Yamamoto, Z. Lukowski, M. Levine, W. Hauswirth, R. Ratnakaram, W. Dawson, W.C. Smith and M. B. Sherwood, Ab-Externo AAV Gene Transfer Delivery to the Suprachoroidal Space Using a 250 Micron Flexible Microcatheter. PLoS One. 2011 Feb 11;6(2):e17140.
  18. Damon E. Welch, MD; Hany Elmariah; Marc C. Peden, MD; Serrhel G. Adams, MD, PhD; Ramakrishna Ratnakaram, MD, OD; Shalesh Kaushal, MD, PhD. Short-term Response of Macular Edema to Intravitreal Bevacizumab, Br J Ophthalmol. 2009 Aug;93(8):1033-6.
  19. Marc Peden, Serrhel Adams, Bryan Huffman, Shalesh Kaushal. An alternative technique for implantation of scleral-fixated intraocular lens, J Cataract Refract Surg. 2009 Feb;35(2):226-9.
  20. Marc C Peden, Arvind Neelakantan,, Christine Orlando,  Shahab A Khan,  Alan Lessner, M. Tariq Bhatti. Breaking the mold of orbital cellulitis, Surv Ophthalmol. 2008 Nov-Dec;53(6):631-5.
  21. Sheets C, Peden M, Guy J. Idiopathic intracranial hypertension in a transgender man. J Neuro-Ophthalmol. 2007:27:313-315
  22. Peden MC, Bhatti MT, Subperiosteal orbital hemorrhage complicating cardiac surgery, Cardiovasc Intervent Radiol. 2004 May-Jun;27(3):294-6.
  23. Robert G. Steen, Anne E. Kwitek-Black, Christopher Glenn, Jo Gullings-Handley, William Van Etten, O. Scott Atkinson, Diane Appel, Simon Twigger, Melanie Muir, Tim Mull, Mary Granados, Mushira Kissebah, Kerri Russo, Robbin Crane, Michael Popp, Marc Peden, Tara Matise, Donna M.Brown, Jian Lu, Stephen Kingsmore, Peter J. Tonellato, Steve Rozen, Donna Slonim, Peter Young, Margit Knoblauch, Abraham Provoost, Detlev Ganten, Steven D. Colman, Jonathan Rothberg, Eric S.Lander, and Howard J. Jacob, A High Density Integrated Genetic and Radiation Hybrid Map of the Laboratory Rat, Genome Research 1999, May.

Non-Referred

  1. Marc C. Peden, Three strategies to help patients adhere to AMD therapy; Part 3 of Wet AMD awareness month. Retina Today. February 2017.
  2. Brockette JT, Davis JL, Peden MC, Tracking the health of a retina practice. Retina Times, Volume: 34, Issue: 67, Winter 2016, page(s): 36-8.
  3. Marc C Peden, Ivan J Suñer, Answers to the three big questions of long-term treatment of wet AMD. Retina Specialist, June 2016: 28-32
  4. Marc C. Peden, Mark E. Hammer, Ivan J Suñer , Fixed-interval dosing of anti-VEGF for wet AMD; Is FIDO the AMD patient’s best friend? Retinal Physician, Volume: 12 , Issue: June 2015, page(s): 23, 28-31.
  5. Tushar Ranchod, Marc Peden, Llewelyn Rao, 3 on 3, perspectives on practice. Retina Practice News, March 2015.
  6. Robert M Knape, Marc C. Peden, The bitter taste of whiplash, Eyenet- AAO publication 2010 Jan: 41-43.
  7. Matthew A Cunningham, Marc C Peden, Donald M. Downer, and Ramakrishna Ratnakaram, Bilateral retinochoroiditis in a case of acute primary toxoplasmosis in an immunocompetent patient, Digital Journal of Ophthalmology,2006 Vol 12, Num 2.

Clinical Trials – Ongoing:

  1. Diabetic Retinopathy Clinical Research Network: Protocols V, AA, W, AB, AC
    Co-investigator  – Aug 2012-current
  2. Genentech LADDER/PORTAL/ARCHWAY Study (NCT02510794) Co-investigator – Dec 2016- current
  3. Genentech A study to evaluate the efficacy and safety of RO6867461 in participants with diabetic macular edema (YOSEMITE) Study (NCT03622580)
    Co-investigator –  Sep 2018- current

Clinical Trials – Completed:

  1. Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations (LCA) – Surgeon/Co-investigator
  2. Genentech RISE Study: Protocol #FVF417G – Principle Investigator
  3. Potentia POT4 Study: Protocol #POT-CP-1006- Co-investigator
  4. Ophthotech: Protocol # OPH2000- Co-investigator
  5. Diabetic Retinopathy Clinical Research Network: Protocols R,S,T,U, – Co-investigator.
  6. REVOLUTIONARY Trial (NCT01247220) – Sub-investigator – Jan 2012-May 2014
  7. ORBIT- Ocriplasmin Research to Better Inform Treatment- Phase 4 observational study. (NCT02079883) – Principal Investigator  – April 2014-Sept 2016
  8. Ophthotech Phase 3 Fovista Trial (NCT01940900) – Co-investigator – April 2014-2017
  9. Genentech Lamapalizumab Study: Co-investigator -Sept 2014-2017
  10. Allergan Abicipar Pegol SEQUOIA (NCT02462486): Co-investigator – Nov 2015- 2018

Honors and Awards

  1. Best Doctors® : Award recipient 2013, 2014, 2015, 2016, 2017
  2. University of Florida Department of Ophthalmology: Resident member of Residency Selection Committee, 2005-2006 and 2006-2007.
  3. Florida Society of Ophthalmology: Florida Resident Delegate to Academy of Ophthalmology Mid-year forum, April 2007
  4. University of Florida College of Medicine
    Gold Humanism Honor Society, Chapman Chapter, 2003-current – Inaugural inductee
    Alpha Omega Alpha Honor Medical Society, 2002-current – Junior inductee
  5. University of Florida – BS in Zoology awarded with High Honors
  6.  

Volunteer/Service

  1. University of Florida College of Medicine Medical College Council, 2000-2003 -Position held- Secretary, 2001-2002, President 2002-2003
  2. University of Florida College of Medicine Equal Access Clinic, 1999-2003 -Positions held- Secretary, 1999-2000, Co-Director, 2000-2001
  3. Alachua County Crisis Center, 1997-1999 – Phone counselor
  4. Nicaraguan Medical Mission, June 1997, 1998, 1999, 2000, 2011
  5. Christ the King Catholic Church, 2014-current – Pastoral Council Chair 2016-current
  6. Society of St Joseph- 2016-current – Chairman 2017-current
  7.  

Interests/Hobbies

  1. Christ the King Catholic Church
  2. Private Pilot- Certificate obtained June 2000- April 2002
  3. Fishing, Boating, Tennis, Gardening, Spending time with family

Employment

  1. Retina Associates of Florida, 2012-current
  2. University of Florida
    1. Assistant Adjunct Professor
    2. Assistant Professor Department of Ophthalmology 2009-2011
  3. Veterans Administration Hospital
    1. Fee basis ophthalmic technician 2005-2006
    2. Fee basis physician 2006- 2009